Journal article 6 views
Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae
Qiu E. Yang,
Siham Rajab Agouri,
Jon Tyrrell 
,
Timothy Rutland Walsh
,
Timothy Rutland Walsh
Antimicrobial Agents and Chemotherapy, Volume: 62, Issue: 5
Swansea University Author:
Jon Tyrrell
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1128/aac.02642-17
Abstract
The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing blaNDM-1 or blaCTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes o...
| Published in: | Antimicrobial Agents and Chemotherapy |
|---|---|
| ISSN: | 0066-4804 1098-6596 |
| Published: |
American Society for Microbiology
2018
|
| Online Access: |
Check full text
|
| URI: | https://cronfa.swan.ac.uk/Record/cronfa70425 |
| Abstract: |
The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing blaNDM-1 or blaCTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in blaNDM-1-positive (48.8% to 71.8%) and blaCTX-M-15-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment. |
|---|---|
| Keywords: |
heavy metal resistance, blaNDM-1 , blaCTX-M-15 , plasmids, coresistance |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Q.E.Y. was funded by a CSC scholarship, and T.R.W. was funded by HEFC. T.R.W. and Q.E.Y. were also supported by MRC grant DETER-XDR-China (MR/P007295/1). |
| Issue: |
5 |