Journal article 53 views
Prevalence of Congenital Ocular Anomalies in 15 Countries of Europe: Results From the Medikeye Study
Charlotte Dubucs 
,
Anthony Caillet,
Félix Frémont,
Laurane Delteil,
Van N'Go,
Amanda Julie Neville,
Elisa Ballardini,
Helen Dolk ,
Maria Loane ,
Ester Garne ,
Babak Khoshnood,
Nathalie Lelong,
Anke Rissmann ,
Mary O'Mahony,
Anna Pierini,
Miriam Gatt,
Jorieke Bergman ,
Maciej Robert Krawczynski,
Anna Latos Bielenska,
Luis Javier Echevarría González de Garibay,
Clara Cavero‐Carbonell,
Marie‐Claude Addor,
David Tucker,
Sue Jordan,
Elly Den Hond,
Vera Nelen,
Ingeborg Barisic,
Florence Rouget,
Hanitra Randrianaivo,
Jonathan Hoareau,
Isabelle Perthus,
Caroline Hurault‐Delarue,
Monique Courtade‐Saïdi,
Christine Damase‐Michel
,
Anthony Caillet,
Félix Frémont,
Laurane Delteil,
Van N'Go,
Amanda Julie Neville,
Elisa Ballardini,
Helen Dolk ,
Maria Loane ,
Ester Garne ,
Babak Khoshnood,
Nathalie Lelong,
Anke Rissmann ,
Mary O'Mahony,
Anna Pierini,
Miriam Gatt,
Jorieke Bergman ,
Maciej Robert Krawczynski,
Anna Latos Bielenska,
Luis Javier Echevarría González de Garibay,
Clara Cavero‐Carbonell,
Marie‐Claude Addor,
David Tucker,
Sue Jordan,
Elly Den Hond,
Vera Nelen,
Ingeborg Barisic,
Florence Rouget,
Hanitra Randrianaivo,
Jonathan Hoareau,
Isabelle Perthus,
Caroline Hurault‐Delarue,
Monique Courtade‐Saïdi,
Christine Damase‐Michel
Birth Defects Research, Volume: 116, Issue: 11, Start page: e2414
Swansea University Author: Sue Jordan
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1002/bdr2.2414
Abstract
Background: Congenital ocular anomalies (COA) are among the most common causes of visual impairment in children in high‐income countries. The aim of the study is to describe the prevalence of the various COA recorded in European population‐based registries of CA (EUROCAT) participating in the EUROme...
| Published in: | Birth Defects Research |
|---|---|
| ISSN: | 2472-1727 2472-1727 |
| Published: |
Wiley
2024
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa68370 |
| Abstract: |
Background: Congenital ocular anomalies (COA) are among the most common causes of visual impairment in children in high‐income countries. The aim of the study is to describe the prevalence of the various COA recorded in European population‐based registries of CA (EUROCAT) participating in the EUROmediCAT consortium. Methods: Data from 19 EUROmediCAT registries and one healthcare database (EFEMERIS) were included in this descriptive epidemiological study. Cases of COA included live births, FD from 20 weeks gestational age (GA), and termination of pregnancy for fetal anomaly. Results: The prevalence of total COA was 3.47/10,000 births (95% CI [3.61–3.82]), ranging from 1.41 to 13.46/10,000 depending on the registry. Among COA cases, congenital lens anomalies were the most frequent anomalies (31%), of which over half were single ocular anomalies (presenting with only one ocular anomaly). An/microphthalmia was the second most frequent COA (24%) of which three‐quarters were multiply malformed (associated to extraocular major anomalies). Among single COA cases, 58 were prenatally diagnosed (4%), of which, 58% were diagnosed in the second trimester. Known genetic causes of COA explained 2.5%–25% of COA depending on their class. Conclusions: This is the first European study describing COA. The detailed prevalence data offered in this study could improve screening and early diagnosis of different classes of COA. As COA are rare, epidemiological surveillance of large populations and accurate clinical descriptions are essential. |
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| Keywords: |
Congenital ocular anomalies, descriptive epidemiological study, epidemiology, Europe, ocular defect |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
The authors received no specific funding for this work. |
| Issue: |
11 |
| Start Page: |
e2414 |